Anastasia era la filla del Emperador Romà [[Constanci I Clor]] i [[Flàvia Maximiana Teodora|Flavia Maximiana Teodora]], i germanastre del Emperador [[Constantí I el Gran|Constantí I el gran]]. '''Anastasia''' va ser associada amb una trama per assassinar el seu germà [[Constantí I el Gran|Constantí.]]<ref name="Crabb">{{cite book|last=Crabb|first=George|title=Universal historical dictionary, or, Explanation of the names of persons and places: in the departments of Biblical, political, and ecclesiastical history, mythology, heraldry, biography, bibliography, geography, and numismatics : illustrated by very numerous portraits and medallic cuts|year=1833|publisher=Baldwin and Cradock, J. Dowding|location=London|page="ANA"}}</ref> Es va descobrir que el seu marit, [[Bassià (cèsar)|Bassià]], havia conspirat contra Constantí.<ref>{{cite book|last=Lightman|first=Marjorie|title=A to Z of ancient Greek and Roman women|year=2008|publisher=Facts On File|location=New York|isbn=9780816067107|page=20|edition=Rev.|author2=Lightman, Benjamin}}</ref>
